STABILITY-INDICATING HPLC DETERMINATION OF ARTEMETHER IN BULK DRUG AND PHARMACEUTICAL FORM
*Milind Ubale and Vilas Choudhari
ABSTRACT
An accurate and precise liquid chromatographic method was developed
for the simultaneous estimation of Artemether in bulk drug and
pharmaceutical form. The chromatographic analysis was performed on
Purospher STAR C-18 250 x 4.0 mm 5μm or equivalent with mobile
phase consisting of Acetonitrile and water (pH- 3.0) in the ratio 62:38
v/v, at a flow rate of 1.5 ml/min and eluent monitored at 216nm. The
retention time for Artemether was found to be 14.641 minutes. The
proposed method is simple, accurate and precise and could be
successfully employed in routine quality control for the simultaneous
estimation of Artemether in bulk drug and pharmaceutical form.
Keywords: Artemether, RP-HPLC, Mobile phase, Column etc.
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