Abstract

SOLUBILITY ENHANCEMENT OF SERTRALINE HYDROCHLORIDE-FORMULATION & COMPARATIVE EVALUATION OF LIQUID SOLID COMPACTS WITH SOLID DISPERSIONS

K.Ratnaraju*, Pasam Jyothirmayi and S.Saibabu

ABSTRACT

Sertraline hydrochloride belongs to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). It is poorly water soluble drug comes under BCS Class II,having only 46% oral bioavailability. The poor dissolution rate is major problem in pharmaceutical manufacturing hence for enhancing the solubility, dissolution and to avoid hepatic metabolism fast dissolving tablets of Sertraline hcl were prepared. The aim and objective of present research study was to formulate and evaluate the fast dissolving tablets of Sertraline hcl by solid dispersion & liquid solid compact techniques. Solid dispersions were prepared by using PVPK30 & urea as carriers. Liquid solid compacts were prepared by using Tween 80 and PEG 400 as non volatile solvents, Avicel PH102 and Aerosil as carrier and coating materials simultaneously. Drug and exciepients are characterized by FT-IR studies. Various formulations were prepared incorporating superdisintegrants such as Crosspovidone, Crosscarmellose Sodium and Sodium Starch Glycolate in different concentrations by direct compression method. The formulated Fast Dissolving Tablets were evaluated for various physicochemical parameters like hardness, friability, thickness, weight variation, disintegration time, drug content and % Cumulative drug release. The results of the evaluation tests indicated that the optimized formulation F20 showed desired release along with good disintegration time and desired release rate for the Sertraline hcl. Different formulations were prepared among the formulations the best formulation shows maximum amount of drug release with in10 mins of time period. With this liquid solid compact method was selected as best method for solubility enhancement of Sertraline hcl.

Keywords: Sertraline hcl, liquid solid compacts, solid dispersions, fast dissolving tablets.