Abstract

ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITIES OF THE AQUEOUS EXTRACT OF THE STEMS BARK OF STRYCHNOS CAMPTONEURA GILG & BUSSE (LOGANIACEAE)

Cyr Jonas Morabandza, Arnaud Wilfried Etou Ossibi, Romaric De Garde Elion Itou, Hermann Gombé Assoungou, Pascal Robin Ongoka, Ange Antoine Abena

ABSTRACT

The aqueous extract of Strychnos camptoneura (Loganiaceae), a medicinal plant of traditional Congolese pharmacopoeia widely used against several pathologies, was studied for antibacterial and antiinflammatory activities by using classical tests. The results showed that aqueous extract inhibits the growth of all studied strains carried out by diffusion in solid medium method. The analysis revealed the IMC of 5 mg/ml for Streptococcus sp and Candida albicans; 6.25 mg/ml for Staphylococcus aureus and 12.25 mg/ml for Escherichia coli, Enterobacter sp and Streptococcus β hemolytic. Aqueous extract BMC was at 50 mg/ml for all strains. At the doses of 300, 600 and 1200 mg/kg aqueous extract of S. camptoneura inhibits significantly oedema induced by carrageenan and formation of granuloma induces by the cotton pellet. The present investigations established pharmacological evidence to support the traditional uses and may open up the possibility of finding the news antimicrobial and antiinflammatory compounds.

Keywords: Strychnos camptoneura, bark, antimicrobial, anti-inflammatory.