REVIEW OF THE FRACTIONATION OF MEDICINES AVAILABLE IN SOLID FORMULATIONS (TABLETS)
Dr. Olga Baudrit*, Eleaneth Baltodano and Luis Jiménez
ABSTRACT
Not always people receive the just dose of active ingredient required
for his health problem. To obtain success in pharmacology treatment,
sometimes the physicians prescribe drugs in a dose that is impossible
obtain in the market because this specific strength does not exist in the
pharmaceutical form that they proposed. This is the case of some
tablets, which need to be divided to achieve this objective. Several
reasons are to justify the need to split pills, since there exist some
consequences of this act in different contexts. Laboratories produce
pharmaceutical forms with Good Manufacturing Practices, but not all
medications are designed to be split. Dividing a scored tablet into two
parts, it is no guarantee to find accurately the half dose in each
fraction. More research is required in Costa Rica, Central America to know the magnitude of
the actual situation in this topic.
Keywords: split tablets, fractionation, drugs, dosage forms, pharmaceutical.
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