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*Namarig Izzeldin Ibrahim Aushi and Muna Abd Almoneim Mohammed Abd Almageed


The recent appearance of a growing number of microbial resistant to conventional antibiotics has stimulated the search for novel antimicrobial agents or lead compounds from a variety of sources, including natural sources. The marine environment is an exceptional reservoir of a wide variety of organisms which are prolific producers of novel and bioactive secondary metabolites with diverse chemical structures and biological activities. This study screens methanol extract of a marine red-Sea coral Tubipora miusica (Tubiporidae) for in vitro antimicrobial activity against four gram (+/-) bacteria and four fungal strains using the broth macro dilution method to determine the minimum inhibitory concentration (MIC) of the extract against the standard microorganisms under the test followed by plating out to determine the minimum lethal concentration (MLC). The MIC was appeared at concentration 1.25 mg/ml against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger and at 0.625 mg/ml against Bacillus subtilis, Aspergillus flavus and Aspergillus fumigates. The MLC of Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans was 2.5 mg/ml and 1.25 mg/ml for Escherichia coli, Aspergillus niger and Aspergillus flavus and 0.625 mg/ml against Aspergillus fumigates. The extract show a good bactericidal and fungicidal activities, All findings sugges that Tubipora musica is a quite promising as antibacterial and antifungal agent.

Keywords: Antimicrobial activity, phytochemical screening, Tupibora musica, methanol extract.

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