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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
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Abstract

IN-VITRO ANTIMICROBIAL SCREENING OF SOME COMMERCIALIZED REGISTERED HERBAL MIXTURES SOLD IN ANAMBRA AND ENUGU STATES, NIGERIA.

Anyaoha Victoria I., Tasie Floretta O., Ezeadila Joachim O.* and Anagonye Calistus O.

ABSTRACT

The antimicrobial activities of some herbal mixtures used for treating typhoid fever, gastrointestinal infections, bronchitis, dental carries and venereal diseases were investigated. Fifteen registered herbal mixtures (coded P1-P15) purchased from Enugu and Anambra States in Nigeria, were screened for antimicrobial activity against clinical isolates of Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Salmonella typhi, Streptococcus mutans and Candida albicans using the Kirby-Bauer disc diffusion method. Ciprofloxacin (5Î¼g/ml) and fluconazole (25Î¼g/ml) were used as standards for comparison. Results showed P1, P2, P6 and P7 were active against one or more of the test organisms. The herbal mixtures P3, P4, and P5 showed only very little activity with inhibition zone diameter ranges of 6.5Â±0.92-10.5Â±1.29mm whereas P8-P15 exhibited no activity. P1 inhibited all the test microorganisms with its highest activity (24.25Â±1.71mm) against Staphylococcus aureus. Also, P7 had the least inhibiting only Staphylococcus aureus with inhibition zone diameter of 16.0Â±0.67mm. The highest zone of inhibition (25.75Â±1.71mm) in this sturdy was produced by P2 against Staphylococcus aureus with MIC and MBC of 0.156mg/ml and 1.25mg/ml respectively. Streptococcus mutans and Candida albicans were resistant to all the mixtures except P1. Staphylococcus aureus was the most sensitive. Statistical analysis showed significant difference (P<0.05) in the sensitivity of test organisms to the herbal mixtures. However, most of the herbal mixtures showed no activity as claimed. This sturdy has shown herbal mixtures possess some antimicrobial activity against some human pathogens but there is need to standardize, monitor and regulate herbal mixtures available in the Nigerian markets for better results.

Keywords: Antimicrobial activity, herbal mixtures, registered, human pathogens.

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