Abstract

A REVIEW ON MOLECULAR MECHANISM OF NEUROINFLAMMATION DISEASE

Vishal Thakur*, Sarvesh Maurya, Mrs. Rachana Sarawade

ABSTRACT

The inflammatory response in the brain associated with most chronic neurodegenerative diseases is termed neuroinflammation. Neuropathological and neuroradiological studies indicate that in certain neurodegenerative disorders neuroinflammation may be detectable years before significant loss of neurons occurs. The evidence from human studies and experimental models that implicate neuroinflammatory processes in the progressive neurodegeneration of the nigrostriatal pathway, the hallmark of Parkinson’s Disease (PD). The neurotoxic role of microglia-derived inflammatory mediators which are suspected to hasten the death of nigral dopaminergic neurons, in particular the proinflammatory cytokine Tumor Necrosis Factor (TNF) and its downstream signaling pathways. The possibility that chronic microglia activation links proteinopathies to neurodegeneration.

Keywords: Neuroinflammation, Cytokines, Chemokines, Proteases, Amyloid precursor protein.