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Surendra Agrawal*, Hardik Shah and P. Gurjar


Andrographolide is water insoluble and belongs to BCS Class II. It is used widely in treating diabetes, diarrhoea and viral infections. Traditionally it is also used for treating peptic ulcer. Andrographolide was obtained by extraction using methanol in soxhlet extractor from Adrographis paniculata leaves, Family Acanthaceae, defatted prior with Petroleum ether. Ethanol extrative value was found to be 2.92% w/w. The extract was subjected to column chromatography. Andrographolide was obtained with repeated column chromatography using chloroform and methanol as a mobile phase. The percentage purity of Andrographolide was 85.84% by densitometric analysis. The obtained Andrographolide was reconfirmed by UV-Visible spectroscopy. FT-IR and TLC. The solubility of Andrographolide was increased to about 13% by Solvent evaporation technique using PEG 6000. Hollow microspheres were developed with emulsion solvent evaporation method. The resulted formulation revealed 74.44% drug content. The formulation was characterized for Particle size, SEM, Floating lag time, Total floating time, Porosity, In-vitro drug release and stability studies. The in-vitro release was found to be 85% in 12 h revealing sustained release from the developed hollow microspheres.

Keywords: Andrographolide; Hollow microspheres; Column Chromatography.

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