“ANTI-ASTHMATIC STUDY OF ETHANOLIC LEAVES EXTRACT OF BIOPHYTUM SENSITIVUM L. IN ASTHMA INDUCED GUINEA PIGS”
Prof. Dr. Mathew George*, Prof. Dr. Lincy Joseph and Umesh Kumar
ABSTRACT
The main objective of this study was to investigate the antiasthmatic
activity of leaves of Biophytum sensitivum L. in guinea pigs. The
ethanolic extract of Biophytum sensitivum L of two doses-100 mg/kg &
200 mg/kg body weight was selected for the study. The preliminary
phytochemical studies showed the presence of steroids, phenolic
groups, cardiac glycosides and flavonoids. The toxicity study showed
that a oral dose of 2000 mg/kg body weight of ethanolic extract of
leaves of Biophytum sensitivum L. is non toxic to guinea pigs and was
compared with the standard drug 'Chlorpheniramine maleate' when
given intraperitoneally. It was concluded from the studies that
ethanolic extract of leaves of Biophytum sensitivum L possess a significant dose dependent
anti-asthmatic activity.
Keywords: Biophytum sensitivum L, Antiasthmatic activity, Chlorpheniramine maleate.
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