SYNTHESIS AND EVALUATION OF ANTHELMINTIC ACTIVITY OF SOME SUBSTITUTED CINNOLOTHIOPHENE DERIVATIVES
Pankaj Shankhdhar* and Vikas Saxena
ABSTRACT
Cinnoline are the six membered heterocyclic compound found to elicit
many pharmacological actions like anti-hypertensive, antithrombotic,
antihistamine, antileukemic, CNS activity, anti tumor, antibacterial and
antisecretory activity. Similarly thiophene moiety is well known for
their therapeutic values. Study was aimed to synthesize some cinnoline
derivatives from substituted anilines and these substituted cinnolines
are further condensed with thiophene moiety and further evaluated
these substituted cinnolothiophene derivatives for biological activity.
Keywords: Cinnoline, Aniline, Anthelmintic activity.
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