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Dr. Nirumal Rakkesh*, Dr. Darling Chellathai and Dr. C. Vasanthi


Objectives: Adverse effects are still one of the major problems in the therapy of many diseases and SAE [serious adverse effects] constitutes more economic burden to patients and therein to society as it might lead to prolonged hospital stay and requires active treatment. Hence this study was undertaken to analyse the incidence of SAE in a tertiary care centre. Methods: This is a retrospective study which analyses the ADRs in inpatients of Sri Ramachandra Medical College for a period of 1 year (May2013 to April 2014). ADR reports was collected, among those patients with SAE were picked out using WHO criteria for SAE and the particulars of these patients were analysed in detail. Results: There were five patients with SAE in this one year period. Out of these, one patient had severe cutaneous reactions all over the body which was produced by cefoperazone and sulbactam. Four were anaphylaxis, each one was caused by cefazolin, cefotaxime, contrast agent and Paclitaxel. All the patients were given symptomatic treatment according to the guidelines and were recovered completely. There were no mortalities. Conclusion: Only very less number of SAE inclusive of anaphylaxis was reported. The patients recovery was also significant as immediate treatment is possible in a tertiary care hospital, still reporting of all adverse effects particularly of SAE by the physicians should be encouraged , so that can lead to more insight of identifying, treating and trying hard to avoid future SAE.

Keywords: Hospital, serious, anaphylaxis.

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