Abstract

REGULATION OF TYPE-1 DIABETES AND ANTIOXIDANT ENZYMES TREATMENT WITH ALOE VERA IN ALLOXAN INDUCED DIABETIC RAT TESTIS

Dr. Ravi Naik Mude*

ABSTRACT

To examine the effects of Aloe vera treatment on the activities of antioxidant enzymes in the testis tissue of Alloxan-induced diabetic rats. Aloe vera leaf gel extract administered orally to different groups of rat at a dose of 300 mg/kg body weight for three weeks. Diabetes was induced intraperitoneally using 40 mg/kg body weight of Alloxan. Three months old male wistar rats were divided into four groups (n=6) namely: Normal, Normal + Aloe vera, diabetic, diabetic + Aloe vera. The experimental period was 21days. The aim of present study was evaluate the Antioxidant effects of Aloe vera leaf Extract in Alloxan induced diabetic rats. Antioxidants associated with a Superoxide dismutase - SOD, Catalase - CAT, Glutathione peroxidase - GPx, Glutathione Reductase - GR and Glutathione-S-transferase- GST statuses were observed in Alloxan induced diabetic rats. The diabetic rates exhibited lower activity levels of SOD, GPx, CAT, GST, and GR in testicular tissue as compared with normal rats. Whereas CAT activity was increased. The activities of SOD, GPx, CAT, GR, and GST were significantly increased in testis tissue of Aloe vera extract treated diabetic rats and CAT activity was decreased. As a results, Aloe vera leaf gel significantly reduced Alloxan induced testicular toxicity for both diabetic and normal rats.

Keywords: Diabetes, Aloe vera, Alloxan, testis, Rat and antioxidant.