EVALUATION OF EFFECT OF VARIOUS SUPERDISINTEGRANTS ON DISINTEGRATION TIME OF ORALLY DISINTEGRATING TABLETS
Dr. Rajashree Hirlekar*, Ankita Dhadhi and Kinjal Mehta
ABSTRACT
Superdisintegrants are used to improve the efficacy of solid dosage
forms. This is achieved by decreasing the disintegration time which in
turn enhances drug dissolution rate. Superdisintegrants are generally
used at a low level in the solid dosage form, typically 1- 10 % by
weight relative to the total weight of the dosage unit. Direct
compression process was selected for this formulation of ODT tablets,
because porous nature is more in direct compression blend than wet
granulation blend, so it will give faster disintegration. Microcrystalline
cellulose was used as diluent and mannitol and sodium saccharin were
used to enhance the organoleptic properties of tablets. The objective of
the study was to compare disintegration times of various commonly
used superdisintegrants in orally disintegrating tablets. It was found
that L-HPC would be effective in providing faster disintegration time.
Keywords: Orally disintegrating tablets, superdisintegrants, direct compression, L-HPC, Croscarmellose sodium, sodium starch glycolate.
[Full Text Article]