Abstract

EVALUATION OF EFFECT OF VARIOUS SUPERDISINTEGRANTS ON DISINTEGRATION TIME OF ORALLY DISINTEGRATING TABLETS

Dr. Rajashree Hirlekar*, Ankita Dhadhi and Kinjal Mehta

ABSTRACT

Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1- 10 % by weight relative to the total weight of the dosage unit. Direct compression process was selected for this formulation of ODT tablets, because porous nature is more in direct compression blend than wet granulation blend, so it will give faster disintegration. Microcrystalline cellulose was used as diluent and mannitol and sodium saccharin were used to enhance the organoleptic properties of tablets. The objective of the study was to compare disintegration times of various commonly used superdisintegrants in orally disintegrating tablets. It was found that L-HPC would be effective in providing faster disintegration time.

Keywords: Orally disintegrating tablets, superdisintegrants, direct compression, L-HPC, Croscarmellose sodium, sodium starch glycolate.