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Ritul B. Gabani*, Dr. H. M. Tank and Nikunj Gabani


The objective of this present study to develop and evaluate bilayer tablet of baclofen. Tablet comprised in two layer i.e. immediate release layer and sustain release layer and in sustain layer gas generating agent add like sodium bicarbonate and citric acid used for floating of tablet in stomach. For immediate release of drug use superdisintegrant like sodium starch glycolate, crospovidone, croscarmellose sodium and for sustain release of drug use hydrophilic natural polymer like guar gum, pectin and xanthan gum. First sustain layer was compressed with low hardness and then final immediate layer was compressed by direct compression method. In Preformulation study FTIR, calibration curve, melting point is done. Results in xanthan gum shows better sustain release up to 24 hours and release maximum drug like 99.10 % than the guar gum (95.30) and pectin (93.50). And in immediate release layer crospovidone release the drug in 15.10 min where SSG and croscarmellose sodium take more time for drug release. 32 factorial design applied and also done dissolution study of all batch and then batch F5 was optimized from result.

Keywords: Tablet, Baclofen, Xanthan Gum, Crospovidone, Dissolution Study.

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