Abstract

ENVIRONMENTALLY BENIGN PROTOCOL FOR THE SYNTHESIS OF SOME NOVEL OXADIAZINANE-4-THIONE DERIVATIVES AS PROMISING AGENT IN BILIARY TRACT DISORDERS TREATMENT

Savita Dhongade-Desai*, Sandeep Kenawade, Valmik Kapase and Sachin Khot

ABSTRACT

Heterocycles containing nitrogen and oxygen have received significant attention because of the unique chemical as well as physical properties of different heterocyclic compounds. Six- membered heterocyclic rings with three hetero atoms are not found widely in the nature, but they have a superfine applications in the most important fields such as medical, as well as agriculture. Oxadiazine compounds are considered to be a supreme type of this family. The aim of the present study was to evaluate biological activity of the newly synthesized [1,3,5]-oxadiazine derivatives. Here we present a protocol for the synthesis of some novel oxadiazinane-4-thione derivatives where the 1,3-dibenzylthiourea [I] was reacted with different substituted aldehydes [II](a-j) by irradiation with microwaves (40% 280 watts) in scientific microwave oven to give different 3,5-disubstituted-2,6-diphenyl-[1,3,5] oxadiazinane-4-thione derivatives. The results clearly demonstrated a high efficiency of the microwave oven systems achieved in the chemical processes. The structures of all these compounds have been confirmed by IR, 1HNMR, mass spectral data and elemental analysis. Library of such oxadiazinane-4- thione derivatives has been generated and the structures were subjected to PASS for their probabilities of being active biologically. Biliary tract disorders treatment, Aspulvinone dimethylallyl transferase inhibitor activities were predicted by PASS. QSAR study of the library was done to find out most active molecules.

Keywords: Oxadiazinane-4-thione, Biological Prediction Study, Microwave Irradiation.