World Journal of Pharmaceutical Research (WJPR) has indexed with various reputed international bodies like : Index Copernicus , Google Scholar , EBSCO Publishing Inc (Academic Search Complete), USA , Indian Science Publications , Urlich's Periodicals Directory, Proquest, UK , NewJour-Georgetown University Library, USA , SOCOLAR, China , eGranary Digital Library, USA , CAS (A Division of American Chemical Society) USA , Research Bible, Fuchu, Tokyo. JAPAN , Science Central, USA , Kaohsiung Medical University Library, CHINA , VIKAS PSOAR (Pharmaceutical Sciences Open Access Resources) , Scopus ((Elsevier Products in process) , EMBASE (Elsevier Products, in process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , Thomson Reuters, USA (in process) , Genamics JournalSeek (In Process) , Hinari Research , Geneva Foundation for Medical Education and Research, Switzerland (In Process) , Lupton Library, (In Process) , Polish Scholarly Bibliography , Virtual Library Pharmacy, Medicine and Health, Biosciences , UDLedge Science Citation Index , Global Impact Factor (0.652) , International Impact Factor Services , Directory of Research Journal Indexing (DRJI) , Universal Impact Factor (0.9861) , International Scientific Indexing, UAE , SJIF Impact Factor (5.045) , Scholar Steer, (Under Process) , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , InfoBase Index (In Process) , Scholar Article Impact Factor, SAIF , CiteFactor , Journal Index (JI, Under Process) , Indian citation Index (ICI) , Indian Citation Index (ICI) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Eurasian Scientific Journals Index (ESJI) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Journalseek Database , Pubmed Database [NLM ID:101644668] (Under Process) , IP Indexing (Under Process) , EBSCO, USA , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) ,

WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Track Your Article

Abstract

FORMULATION AND EVALUATION OF AN OPHTHALMIC IN-SITU GEL OF GENTAMICIN SULPHATE

Ashish Namdeo, Santosh Bhadkariya, Akanksha Garud*, Navneet Garud

ABSTRACT

The aim of the present study is to prepare and evaluate an ophthalmic in-situ gel formulation of gentamicin sulphate. The different gelling solutions were made with Pluronic F127 in combination with different polymers such as Carbopol 934 and HPMC, which acted as a viscosity‐enhancing agent. Suitable concentrations of buffering agent were used for pH adjustment. All the formulations were sterilized in an autoclave at 121°C for 15 minutes. The formulations were evaluated for clarity, pH measurement, gelling capacity, drug content, rheological study, sterility testing, in vitro drug release study, antibacterial activity, ocular irritation study and stability study. The developed formulations exhibited sustained release of drug from formulation over a period of 8 hours. The prepared formulations were tested for eye irritation on albino rabbit (male). The formulations were found to be non-irritating. Thus, the in situ gelling systems may be used as an alternative to the conventional systems.

Keywords: Gentamicin sulphate, in situ gel, in vitro drug release, rheological study.

[Full Text Article]