DENDRIGEL: PREPARATION, OPTIMIZATION AND CHARACTERIZATION
*Amanjot, Shalu Rani, Harjaskaran, Lovepreet Singh, Surya Prakash Gautam and Sukhbir Kaur
ABSTRACT
The preparation of dendrigel, using dendrimers as drug carrier.
Dendrimers were prepared by divergent method and was loaded in
varying proportion in carbapol 940. To this mixture itraconazole drug
was added and the formulation of dendrigel was evaluated. Dendrimers
was prepared by divergent growth method. Evaluation parameter such
as colour test, UV spectroscopy, FT-IR. Evaluation parameters for
dendrigel were pH, spreadability, viscosity, drug content, antifungal
activity and in vitro release studies. The prepared dendrigel having
better antifungal activities than other conventional delivery system
because dendrimers were enhance the solubility of drug which results
in increase in penetration of drug in the skin.In the present study
attempt was made to develop dendrimers containing itraconazole as a drug so as to increase
the solubility and penetration of the drug through the skin using novel delivery system for
better antifungal activity.This will help to increase the solubility and penetration of drug. It
increases the antifungal activity of formulation.
Keywords: PAMAM, dendrimer, dendrigel, nanoparticles, FT-IR, UV spectroscopy.
[Full Text Article]