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Upadhyay R.K.*, Gupta R.K., Prajapati K.K. and Ahmad S.


In the present investigation different Cassia alata solvent extracts were
evaluated for its toxic effects on T. castaneum in the laboratory. Its
effect was observed on changes in the level of different bio-molecules
and certain metabolic enzymes of T. castaneum at different time
periods i. e 4hr, 8hr, 12hr and 16hr following sub-lethal (40% and 80%
0f 24-h LD50) exposures different solvent extracts of C. alata was
studied. Six extracts were applied for obtaining LD50 values. The LD50
values of acetone, chloroform, petroleum ether, methanol, hexane and
water was found to be very low i.e. 0.840μg/gm, 0.510μg/gm,
0.590μg/gm, 1.57μg/gm 0.310 μg/gm and 2.50μg/gm respectively.
Activity of different bio-molecules i. e. glycogen, protein, DNA, RNA and amino acids in
treated beetles (T. castaneum) was significantly (p<0.05) decreased after 16 hr treatment in
comparison to control beetles. Hexane extract have shown higher depletion i.e. 51.39%,
40.82%, 28.25%, 32.18% and 28.33% in glycogen, protein, DNA, RNA and amino acids
respectively. Same Above extract have potentially inhibit the activity of acid phosphatase
(54.85%), alkaline phosphatase (60.71%), glutamate pyruvate transaminase (62.69%) and
glutamate oxaloacetate transaminase (72.37%), lactic dehydrogenase (85.46%) and
acetylcholinesterase (63.51%) and obstruct the physiological homeostasis. Low LD50 values
obtained in different fractions and its action on enzymes and other biomolecules indicates
that Cassia alata possess potential candidates that can be used for control of T. castaneum
and other stored grain insects.

Keywords: Tribolium castanem, Cassia alata, Enzymatic changes, bio pesticides.

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