Abstract

MICROWAVE ASSISTED SYNTHESIS OF SOME NEW THIAZOLIDIN-4-ONE DERIVATIVES CONTAINING A PYRIMIDONE AND QUINOLINE MOITIES.

Nilesh Mohan Gosavi*

ABSTRACT

A series of substituted thiazolidin-4-ones [IV(a-j)] were synthesized by the reaction of substituted schiff’s bases [III(a-j)] with thioglycolic acid in presence of zinc chloride for 3-4 minutes in Microwave irradiation. The schiff’s bases [III(a-j)] were in turn obtained by the substituted pyrimidine carboxylic acid hydrazide [II(a-j)] and 2-chloroquinolene- 3-carbaldehyde with the help of Microwave irradiation. The structures of the synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR spectral analysis.

Keywords: thioglycolic acid, carboxylic acid.