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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

EFFECT OF BINDER TYPE AND CONCENTRATION ON PHYSICAL AND IN VITRO PROPERTIES OF DICLOFENAC POTASSIUM 50MG TABLET

Alaa E. Elawni*, Mohammed Abdeen, Waleed Elballa, Abdelrhman Abdelkreem, Abutalib Alamin Abdallah

ABSTRACT

The aim of this study is to investigate the effect of different binder types on the pharmaceutical properties of Diclofenac potassium tablets. Nine formulation runs were prepared using 3 binders: Microcrystalline cellulose 101 (VivapurÂ® 101), Pregelatinized starch (LycatabÂ®) and Maize starch. Each used in 3 different concentrations (15%, 35% and 55%).All the formulation runs were subjected to weight variation, hardness, friability, disintegration time and dissolution tests. The results have shown that different binders with different concentrations will result in different weight variation, hardness, friability, disintegration time and dissolution profile (drug release).From this study it has been concluded that using maize starch as a binder with 35% concentration led to the best physical properties with acceptable dissolution profile regarding similarity with the originator (CataflamÂ®).

Keywords: Diclofenac potassium, binder type, binder concentration, dissolution profile, similarity factor.

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