Abstract

FORMULATION AND EVALUATION OF HERBAL ANTIAGING GELCREAM OF AZADIRACHTA INDICA AND CURCUMIN

Pramod Kumar*, Nisha Thakur and Niladry Sekhar Ghosh

ABSTRACT

Skin appearance is a primary indicator of age. With the advent of retirement age, there has been an increased interest in anti-aging preparation, or cosmeceuticals and their purported ability to enhance a person’s more youthful appearance. The topical formulations used to treat ageing are creams and transparent gels. These preparations have several disadvantages like low moisturizing ability, poor spreadability, slower drug permeation and stability problems. To overcome these lacunae, a novel gel-cream formulation can be developed. A gel-cream consists of oily and aqueous phases together with a stabilizing, thickening and/or emulsifying agent. Gel-cream has a smooth texture, good spreadability, feel and provides good nourishment with mositurization. It has rapid drug permeation and is also thermodynamically stable. Herbal anti-oxidants are more advantageous than synthetic drugs because they fight against the free radical and provide nourishment to the skin causing rejuvenation at the same time. Herbal gel-cream was prepared by mixing extracts with gel-cream base containing gelling agent, surfactant, preservatives, moisturizers etc. Physico-chemical parameters were evaluated to assure the quality of the gel-cream. Stability study of the formulated gel-cream was done according to ICH guidlines. Anti-oxidant activities of the extracts and formulation were determined by DPPH assay. The plant extracts shows the significant anti-oxidant activities. The formulations pass all the physical and pharmaceutical parameters. In the stability studies there were no considerable changes. The gel-cream was stable and posseses all the parameters. The formulation F3 posseses good anti-oxidative and physico-chemical properties.

Keywords: Antiaging, anti-oxidant, poly herbal, gel-cream, curcumin, neem, DPPH.