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K. Navaneetha*, Ch. Ramakrishna, Krishna Mohan Chinnala and Basu Venkateswara Reddy


The present work is aimed to develop a sustain release microspheres for sitagliptin, a antihyperglycemic drug by employing polymers such as albumin and chitosan. These polymers have been taken in various proportions and the effect of these polymers on the drug release pattern is studied. Total of nine formulations have been developed and were evaluated for various parameters to determine the nature of the prepared formulations. All the formulations have shown good micromeritic properties and it has revealed that the microspheres has good flow properties by which it can be easily filled into capsules if desired. The other properties of microspheres such as entrapment efficiency, percentage yield, drug content, particle size and swelling index values were optimum. From the in-vitro drug release studies it is found that albumin and chitosan in the ratio of 3:1 and drug: polymer ratio of 1:2 has shown maximum drug release of 83.91% at the end of 12 hours and is thus optimized and the drug release from this optimized formulation was by diffusion of drug molecules from the polymer matrix.

Keywords: Sitagliptin; Microspheres; Antihyperglycemic; Albumin; Chitosan.

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