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G. V. Radha*, U. Manasa and R. Krishna Chaitanya


Proniosomes are water-soluble carrier particles that are coated with surfactant and can be measured out as needed and dehydrated to form niosomal dispersion immediately before use on brief agitation in hot aqueous media within minutes. Provesicular systems, such as proniosomes which is one of the advancement in nanotechnology minimize problems of vesicular systems. This research mainly emphasizes on formulating Ketoconazole Proniosomal gels with span surfactants, cholesterol, soya lecithin and alcohol as aqueous phase. These are prepared by coacervation phase separation method and the prepared formulations are characterized for FTIR studies, Encapsulation efficiency, size distribution and In vitro release studies were carried. FTIR studies showed that there was no interaction between API and used excipient. The encapsulation efficiency of Proniosomal formulations are in the range of 55% to 69.94%. Morphological size and shape of the vesicles are characterized by using optical microscopy and scanning electron microscopy, particles are found to be spherical, size of the particles are in the range of 3.29μm to 30μm and permeation studies showed good control release for prolonged period of time. Span20 Non lecithin formulation showed highest amount of drug release of 74% in 24 hours.The results suggest that ketoconazole proniosome formulations can be used for Topical drug delivery system for the treatment of skin infections.

Keywords: Proniosomal Gel, Ketoconazole, Nanotechnology, Formulation.

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