TOBACCO USE AND ITS RELATION TO RAISED TOTAL IGE CONCENTRATION AND INCREASED RISK OF TYPE 1 HYPERSENSITIVITY REACTION AMONG MALES IN KHARTOUM, SUDAN
Rayan Hamid, Samah Abdulrahman, Hind Abdumoneam, Mohammed Abdulazeem, Rayan Abo Baker, Zohel Bakheet, Fatima ashmaig, Abdelbagi Elfadil, Mohamed Mahmoud Khidr and Rasha Elbushra Abdulhameed*
ABSTRACT
Background: Continued tobacco use has been shown to affect both
humoral and cellular immune responses. Cigarette smoke as well as
other tobacco forms impairs the integrity of the lung epithelial layer
and facilitates the penetration of allergens by compromising the innate
defense mechanisms in the lungs. Thus, smoking may be stated to
induce predisposition to atopy. Symptoms of cigarettes allergy are
similar to asthma which includes, shortness of breath, wheezing,
coughing and impaired lung function. Objectives: To investigate the
effect of different tobacco products on serum total IgE concentration
among healthy males in Khartoum, Sudan. Materials and methods:
This prospective case control study was conducted in Khartoum, Sudan
and involved 119 healthy males who age between (18-35) years. Study
subjected were classified into five groups: 19active smokers, 13water
pipe smokers, 18 smokeless tobacco users, 22 passive smokers and 35 non-tobacco users
(controls). Demographic data was collected from each participant in a data collection sheet
and a written informed consent was obtained from all participants. Serum samples were
analyzed quantitatively using The ELISA test kit for detection of human antibodies of the IgE class. Results: A tremendous increase in IgE mean SD level have been demonstrated among tobacco consumers (302±154) compared to non-users, mean SD level (120.5±143), and this elevation was more obvious among males who use combination of all three forms of tobacco (415±500). Conclusion: This study concluded that tobacco use among Sudanese males could be on of today's leading public health problems and may play a major role on the progression of hyper sensitivity reactions and allergic responses.
Keywords: shortness of breath, wheezing, coughing and impaired lung function.
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