SCREENING OF ANTIDIABETIC (HYPOGLYCEMIC/ANTIHYPERGLYCEMIC) ACTIVITY OF EXTRACTS OF SPIRULINA AGAINST ALLOXAN INDUCED DIABETES IN RATS.
Panigrahi B.B.*, Quamuddin M., Panda P.K. and Patro V.J.
ABSTRACT
Spirulina is a cyanobacterium, blue green algae, belongs to
cyanophyceal, a prokaryotic form. Spirulina was extracted through Pet-
Ether, chloroform and methanol by Soxhlet’s extraction process. After
making phytochemical analysis, duly confirmed through TLC
proceeded for hypoglycemic activity. The antidiabetic activity of
different extracts of spirulina was carried out using albino rats of
either sex, diabetes was induced 12 hour fasted rats by intra peritoneal
injection of alloxan. Rats with 250 mg/dl plasma glucose level were
selected for experiment. Petrolium ether, Chloroform extract did not
lower the blood glucose level. However Methanolic extract of
Spirulina significantly reduced the blood glucose level. Standard drug
used in this research study is Metformin.
Keywords: Spirulina, Petrolium Ether, Chloroform, Metformin, Methanolic extract.
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