WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Masood Shah Khan, Mhaveer Singh, Mohammad Ahmed Khan, Sayeed Ahmad*


Doxorubicin (DOX), the use of (a potent antitumor antibiotic) has been limited due to generation of ROS followed by the development of lifethreatening cardiomyopathy. The aim of this study was to determine the protective effect of aqueous extract of Santalum album in acute doxorubicin induced cardiotoxicity. Since it is the part of several unani and ayurvedic formulations used for cardioprotection since long. Thirty male wistar rats used in study were divided in five groups v.i.z. normal control, doxorubicin control, standard control, test sample Dose 1 and Dose 2. The study was carried out up to 31 days and animals were sacrificed on 32nd day. It was found that doxorubicin treatment increased MDA, LDH, CK-MB levels significantly (P < 0.01), which were decreased by administration of S. album aqueous extract (SAAE) and desferrioxamine, significantly. The level of IL-6 and TNF-α in serum whereas caspase-3 in cardiac tissue were also reversed significantly on administration of SAAE. The histopathological studies showed that administration of S. album attenuated the sign of vacuolization and myocardium structure appears to be restored compared with DOX only group. There is a marked reduction of vacuolization and myocardium appears to be normal in desferrioxamine treated group. Antioxidant effect of SAAE has been shown to decrease doxorubicin induced cardiotoxicity.

Keywords: Santalum album, doxorubicin, in-vitro, cardiotoxicity

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More