COMPARATIVE STUDY ON EFFECT OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT ON FORMULATION OF SUBLINGUAL TABLET OF AMLODIPINE BESYLATE
Raosaheb R. Dhangar*, Dr. S. T. Patil, S. A. Tadavi and Dr. S. P. Pawar
ABSTRACT
Amlodipine besylate which is generally taken to reduce hypertension.
In this study an attempt has been made to formulate a dosage form of
amlodipine using synthetic superdisintegrant crosscarmellose sodium
to show that this synthetic superdisintegrant will show better
disintegrating property than the natural superdisintegrant like sodium
guar gum in the formulation of sublingual tablet of amlodipine
besylate. Sublingual tablet prepared by direct compression technique
using natural & synthetic superdisintegrant in different concentration
& evaluated. Among all F6 is an optimized formulation of
crosscarmellose sodium that releases the drug above 90% within 60
min. as compared to all formulations of natural superdisintegrant which is a guar gum
preparation.
Keywords: Amlodipine besylate, sublingual tablets, Superdisintegrant.
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