ANTI-OBESITY ACTIVITY OF IPOMOEA SEPIARIA EXTRACTS IN RATS FED WITH HIGH FAT DIET
Pavan Kumar Chadalawada*, B. Pooja, S. Manoharbabu, M. Prabhu Teja, M. Janbee, B. Himabindu and D. Srividya
ABSTRACT
Objective: Overweight and obesity represent a rapidly growing threat
to the health of populations in an increasing number of countries.
Indeed they are now so common that they are replacing more
traditional problems such as undernutrition and infectious diseases as
the most significant causes of ill-health so we have made an attempt
for in-vivo anti- obesity activity. Methods: in-vivo effect of Ipomoea
sepiaria methanol and aqueous on HFD induced Obesity by using
Wistar strain rats. Results: To results from this study, test item
Ipomoea sepiaria aqueous and methanol extract at a dose of 200 & 200 mg/kg and reference
compound Atorvastatin (10 mg/kg) were effective in reducing Obesity and atherosclerosis
induced by HFD in Wistar rats. Hence, the test item Methanolic extract of Ipomoea sepiaria
could be considered for treatment of Obesity in human beings Conclusion: our findings on
therapeutically properties of Ipomoea sepiaria aqueous extract on lipid levels progression
showed that positive pharmacological effects of Ipomoea sepiaria aqueous and methanol
extracts is not completely due to flavonoids and at least in part, it is attributed to the presence
of higher amounts of other constituents such as polyphenols, tannins. Thus the plant can be
further explored for its phytochemical profile to identify the active constituents for the above
mentioned activities.
Keywords: obesity, Ipomoea sepiaria, HFD induced Obesity, analogous design.
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