Abstract

ANTI-OBESITY ACTIVITY OF IPOMOEA SEPIARIA EXTRACTS IN RATS FED WITH HIGH FAT DIET

Pavan Kumar Chadalawada*, B. Pooja, S. Manoharbabu, M. Prabhu Teja, M. Janbee, B. Himabindu and D. Srividya

ABSTRACT

Objective: Overweight and obesity represent a rapidly growing threat to the health of populations in an increasing number of countries. Indeed they are now so common that they are replacing more traditional problems such as undernutrition and infectious diseases as the most significant causes of ill-health so we have made an attempt for in-vivo anti- obesity activity. Methods: in-vivo effect of Ipomoea sepiaria methanol and aqueous on HFD induced Obesity by using Wistar strain rats. Results: To results from this study, test item Ipomoea sepiaria aqueous and methanol extract at a dose of 200 & 200 mg/kg and reference compound Atorvastatin (10 mg/kg) were effective in reducing Obesity and atherosclerosis induced by HFD in Wistar rats. Hence, the test item Methanolic extract of Ipomoea sepiaria could be considered for treatment of Obesity in human beings Conclusion: our findings on therapeutically properties of Ipomoea sepiaria aqueous extract on lipid levels progression showed that positive pharmacological effects of Ipomoea sepiaria aqueous and methanol extracts is not completely due to flavonoids and at least in part, it is attributed to the presence of higher amounts of other constituents such as polyphenols, tannins. Thus the plant can be further explored for its phytochemical profile to identify the active constituents for the above mentioned activities.

Keywords: obesity, Ipomoea sepiaria, HFD induced Obesity, analogous design.