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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

VALIDATED ABSORPTION CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF ROSUVASTATIN CALCIUM AND EZETIMIBE IN TABLET DOSAGE FORM

*V. Raut and T.V. Walke

ABSTRACT

A new, simple, accurate and sensitive UV-Spectrophotometric absorption correction method has been developed and validated for simultaneous determination of Rosuvastatin calcium (RSV) and Ezetimibe (EZE) in a tablet dosage form. Methanol and distilled water (70:30) was used as a solvent. The wavelengths selected for analysis were 300 nm and 242.80 for Rosuvastatin calcium and Ezetimibe respectively. Beer’s law obeyed the concentration range of 10-35 mcg/ml for Rosuvastatin calcium and 5-30 mcg/ml for Ezetimibe. The percentage recovery was found in the range of 99.34% - 100.2% for Rosuvastatin calcium and 100.02% - 102.49% for Ezetimibe. The mean percentage drug content for Rosuvastatin calcium and Ezetimibe was found to be 103% and 108% respectively and % RSD value was found to be less than 2 which shows the precision of method. The developed method was validated statistically and by recovery studies. Thus the proposed method is simple, precise, economic, accurate and can be successfully applied for simultaneous determination of Rosuvastatin calcium and Ezetimibe in tablet dosage form.

Keywords: Rosuvastatin calcium, Ezetimibe, Absorption correction method, Spectrophotometer, Validated.

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