Abstract

"QUANTIFICATION OF CREATINE PHOSPHOKINASE LEVELS IN CHRONIC PERIODONTITIS"

Dr. Nagaraj B Kalburgi, Dr. Arati C Koregol, Dr. Priya Sinha*, Dr. Shivaraj Warad, Dr. Jyoti Pattanshetti and Dr. Sireesha K. Sadasivan

ABSTRACT

Introduction: Periodontitis is a chronic inflammatory state characterized by persistent inflammation, annihilation of connective tissue and alveolar bone. Creatine phosphokinase an intracellular enzyme, is a steadfast indicator of cellular damage and their increased activity is a reflection of metabolic changes in inflamed gingiva. Creatine phosphokinase in plaque seems to capture the host response to periodontopathogens. Study regarding creatine phosphokinase in periodontal disease will provide new opportunities in diagnosis and treatment. Obejectives: To quantify the level of plaque creatine phosphokinase level in healthy and chronic periodontitis subjects and to compare and correlate it with bleeding on probing, gingival index, plaque index, pocket probing depth and clinical attachment level. Methodology: 120 subjects were divided into 2 groups: 60 healthy and 60 chronic periodontitis. Plaque samples of patients were collected after obtaining duly signed consent and analyzed by using liquixx Creatine Kinase kit. Statistical analysis was done by Mann whitney U test and Spearmans corelation test. Results: A statistically significant increase in plaque creatine phosphokinase levels was found in chronic periodontitis subjects (1.4 ± 4.4) compared to healthy (0.2 ± 1.4).Clinical parameters were positively correlated with increasing creatine phosphokinase levels. Conclusion: Intracellular enzymes are released from damaged cells of periodontal tissue. Creatine phosphokinase can be used as reliable biochemical markers for functional condition of periodontal tissues and therapeutic intervention.

Keywords: Creatine phosphokinase, Chronic periodontitis, enzyme.