Abstract

NOVEL CLINDAMYCIN LOADED TRANSFERSOMES FORMULATION FOR EFFECTIVE MANAGEMENT OF ACNE

Madhur Gupta*, Ram Narayan Prajapati, Dr. Raghuveer Irchhaiya, Nandlal Singh, Sunil Kumar Prajapati

ABSTRACT

Acne vulgaris is a chronic inflammatory disease affecting many millions people in the world. The aim of the present study was to improve the therapeutic effectiveness of clindamycin via encapsulation it into a nanocarrier namely transfersome. total eight formulations prepared for optimization of Clindamycin loaded transfersomes (TE1- TE8) using varying amount of span 80, and phosphatidylcholine, the prepared transfersomes were evaluated for vesicle size determination, entrapment efficiency and surface Morphology. In all formulations formulation TE4 which contain smallest vesicle size and increase in entrapment efficiency which was selected as optimized formulation for topical gel preparation. The clindamycin encapsulation was found to increase the skin residence time leading to a faster healing of external lesions and to a reduction of side effects and duration of therapy.

Keywords: Clindamycin, transfersomes, topical gel.