Abstract

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF BARLERIA LONGIFLORA L.f. AND POTENTILLA ANSERINA LINN

*Rajaputana Lakshmi Manisha Ph.D and Dr. Meera Sumanth

ABSTRACT

Aim: Evaluation of aqueous and ethanol extracts of leaves of Barleria longiflora L.f. and whole plant of Potentilla anserina Linn for antiinflammatory activity using Carrageenan induced paw oedema in rats. Materials and method: Animals were divided into 10 groups of 6 rats. Groups 1 and 2 served as Carrageenan induced control and standard (Diclofenac 5 mg/Kg, i.p.) respectively. Groups 3 and 4 were treated, orally with aqueous extract of Barleria longiflora L.f. with 100 and 400 mg/kg b.w, respectively. Groups 5 and 6 were administered, orally, ethanol extract of Barleria longiflora L.f. with 100 and 400 mg/kg b.w, respectively. Groups 7 and 8 were received, orally, aqueous extract of Potentilla anserina Linn of 100 and 400 mg/kg b.w, respectively. Groups 9 and 10 were administered, orally, ethanol extract of Potentilla anserina Linn of 100 and 400 mg/kg b.w, respectively. The paw volume was measured at 0, 1, 2, 3 and 4 hr after carrageenan injection. The actual edema volume was calculated. The data was expressed as mean ± S.E.M. The statistical analysis was done by means of ANOVA followed by Dunnett‘s post hock test. Results: The aqueous and ethanol extracts of leaves of Barleria longiflora L.f. and whole plant of Potentilla anserina Linn exhibited significant reduction of edema in the rats. Conclusion: Ethanol extract of whole plant of Potentilla anserina Linn revealed superior anti-inflammatory activity.

Keywords: Barleria longiflora L.f., Potentilla anserina Linn, inflammation, carrageenan, edema.