IN-VITRO ANTHELMINTIC ACTIVITY OF HYDROETHANOLIC EXTRACT OF CALOTROPIS GIGANTEA LEAVES
Bhosale Vishal*, Bhokare Pallavi and Khadke Anand
ABSTRACT
Calotropis gigantea a giant milk weed, is known for its
pharmacological importance for centuries. The coarse shrub is a very
prom ising source of anticancerous, ascaricidal, schizonticidal,
antimicrobial, anthelmintic, insecticidal, anti-inflammatory, antidiarrhoeal,
larvicidal with many other beneficial properties. Plant is
described as a golden gift for human kind containing calotropin,
calotropagenin, calotoxin, calactin, uscharin, amyrin, amyrin esters,
uscharidin, coroglaucigenin, frugoside, corotoxigenin, calotropagenin
and voruscharine used in many therapeutic applications. Different
compounds like norditerpenic esters, organiccarbonates, the cysteine
protease procerain, alkaloids, flavonoids, sterols and numerous cardenolides made this plant
of scientific attraction for centuries. Different extracts of Calotropis gigantea leaves were
found to possess invitro anthelmintic activity against Indian earthworms Pheritimaposthuma,
using piperazine citrate as reference standard. Dose dependent activity was observed in
extracts of plant leaves. 70% hydroethanolic extract shown better activity of Calotropis
gigantea leaves. No work was reported on the part of leaves of Calotrops gigantea shows
anthelminthic activity.
Keywords: Calotropis gigantea , Pheritimaposthuma, piperazine citrate, Anthelmintic activity.
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