Abstract

FORMULATION AND EVALUATION OF HERBAL WOUND HEALING FORMULATION OF CENTELLA ASIATICA

Pawan Kudale, Padmanabh Deshpande*, Mangesh Bhalekar, Vishal Tayde, Sonali Sangle

ABSTRACT

Wounds are physical injuries that results in a gap or infringement of the skin. Proper healing of wounds is very essential for the reestablishment of disrupted anatomical continuity and disturbed functional status of the skin. Wound healing is a complex but usually systematic process. Sequential waves of specialized cell types first clear the inciting injury and then progressively build the scaffolding to fill in any resulting defect. Cream is defined as semisolid emulsions which may be oil in-water (o/w) or water- in- oil (w/o) type and these semisolid emulsions are meant for external applications. In this study, we have formulated an herbal cream (O/W type) fulfilling almost all the pharmaceutical parameters which showed better tissue regeneration and healing power. The formulated herbal cream contains a mixture of Centella asiatica extract, corn oil (used to reduce the surface tension), cetyl alcohol (moisturizer), sodium lauryl sulphate (anionic detergent and surfactant), glyceryl monosterate, propyl paraben (Preservative), Methyl paraben (anti-fungal agent) and purified water (vehicle). The pH of the formulated cream was found to be 7.00 which is good for skin. The creams also showed good Hardness (9.21 g.cm/sec) when measured using a texture After application of the cream the type of smear formed on the skin was found to be non-greasy and easily removed on washing with tap water. The viscosity of the creams was found to be 2150 cps, with 25 rpm, which indicates that the prepared cream was easily spreadable with small amount of shear.

Keywords: Cream, O/W emulsion, TLC, Formulation.