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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

A SIMPLE SPECTROPHOTOMETRIC ASSAY OF LAMIVUDINE IN PHARMACEUTICAL FORMULATIONS

G. Srihari, K. Prabhavthi, N. Umamaheswar Reddy and N. Rami Reddy*

ABSTRACT

A simple, sensitive and accurate spectrophotometric method has been developed for the estimation of lamivudine in bulk and pharmaceutical dosage forms. The amino group in lamivudine is diazotised with sodium nitrite and hydrochloric acid at 0oC temperature. After diazotisation, the diazonium salt is coupled with resorcinol. The orange red coloured chromogen formed in the method is stable for more than 24 hours. The orange red coloured chromogen is measured at the wavelength of maximum absorbance 460 nm against the reagent blank. The results obtained with the proposed method are in good agreement with labeled amounts, when marketed pharmaceutical preparations are analyzed.

Keywords: Spectrophotometry, resorcinol, lamivudine, Pharmaceutical and Formulation.

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