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N. Verma, M. Mittal, V. Awasthi, Kiran Tiwari and G. Lamgora*


Background: Obesity and overweight are medical conditions which are characterized in the obese individuals by body mass index (BMI) of more than 30 kg/m2 and 25 kg/m2, respectively. Several environmental, nutritional & hormonal factors imbalances the energy between calories consumed and calories expended, which develops obesity and overweight. GCB-70, which is a green coffee bean extract, contains phenolic compounds such as chlorogenic acid which contributes towards the anti-obesity property of it. Chlorogenic acid in GCB-70 is believed to reduce the generation of new fat cells along with the enhancement of thermogenesis i.e. the natural burning of fat for energy in the body. Methodology: This was an open-labeled, single centric & single armed clinical study conducted in 100 overweight or obese subjects to evaluate the anti-obesity effect of GCB-70. GCB-70 with 70% chlorogenic acid of was consumed orally as 500mg capsule by both male & female patients as BD dosage for 12 weeks. Results: GCB-70 was proved to be effective and safe in both the male & female obese individuals. There was 6% significant decrease in the mean body weight of the enrolled subjects till the completion of the treatment as compared to the baseline levels (p-value: 0.000**). BMI was also observed to be significantly decreased up to 5.65% in the 96% study population (p-value: 0.000**). Waist circumference of the male subjects was reduced up to 6.77% and of female subjects up to 6.62% on completion of treatment. The plasma leptin levels were also decreased significantly up to 13.59% till the completion of treatment. There were no abnormal alterations in the biochemical parameters (ALT, AST and ALP) & hematological parameters (Hb, TLC and DLC) in the enrolled subjects on completion of the treatment. Conclusion: It can be concluded from this clinical study that GCB-70 is completely effective and safe for the clinical management of obesity and its complications in the obese subjects.

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