Abstract

POSSIBLE ANTI-INFLAMMATORY MEDIATED WOUND HEALING ACTIVITY OF PYRAZINAMIDE AND CLOFAZEMINE IN WISTAR RATS

Vivek Sonwane*, Ashok Pakhare, Pawan Kudale, Rahul Somani, Sachin Tembhurne and Priyank Shenoy

ABSTRACT

Inflammation is defined as a sequence of events that occurs in response to noxious stimuli, infection or trauma. Symptoms of inflammations are local redness, swelling, pain, heat and loss of function. The present study was performed to evaluate the anti-inflammatory and wound healing activity of pyrazinamide and Clofazemine in Wistar rat. The aim of present work is to study the screening of synthetic compounds for its pharmacological aspects in inflammation and wound healing activity by using various preclinical models of wound healing and inflammation.The both drugs were studied for their anti-inflammatory activity by using carrageenan-induced paw edema in rats and the mean increase in paw volume in paw volume were measured by plethysmometer at different time intervals after carrageenan (1% w/v) injection. The pyrazinamide and Clofazemine were further evaluated for wound healing activity using incision wound model. The pyrazinamide and Clofazemine showed significant (p<0.05) reduction in the carrageenan-induced paw edema in rats and incision wound healing activity evidenced method in Wistar rats. The pyrazinamide and Clofazemine showed a greater antiinflammatory and wound healing effect when compared with the standard drugs, indomethacin and povidone iodine respectively. The present observation indicated significant (p<0.0001) activity of the pyrazinamide and Clofazemine in the treatment of inflammation and wound healing.

Keywords: Inflammation is defined Clofazemine injection.