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Sana Javaid Awan*, Rubyia Yousaf, Maaida Ajmal, Ammad Tanvir, Kanza Tariq, Saba Boota, Fahim Hadi, Tahir Maqbool and Ayesha Tariq


Background: Renal cell carcinoma (RCC) is known to the hazardous of all urogenital manifestations. The growth, invasion, and metastasis of RCC is critically depends upon angiogenesis. Further, cells of RCC are known to be in extreme oxidative stress. Based upon these facts, this study was design to evaluate the potential of RCC patient derived serum for tumor angiogenesis via measuring its vascular endothelial growth factor (VEGF) levels and anti-oxidative enzyme index in order to comprehend the metastasis of RCC in Pakistani Population. Methodology: Serum samples of 100 patients of RCC and 100 normal person were taken from Agha Khan Laboratory of Lahore, Punjab after due consent of patients and lab authorities. Tissue samples were collected from 50 RCC patient biopsies. VEGF levels were measured by immunostaining and Sandwich ELISA method. Estimation of anti- oxidative enzymes in serum samples was done by estimating the levels of superoxide dismutase, ascorbate peroxidase, glutathione reductase and catalase. Results: Levels of VEGF were increased in RCC group than in normal ones representing augmented angiogenesis. Moreover, increased lactate dehydrogenase levels a valuable biomarker for monitoring the prognoses of RCC indicates lower overall survival of the patients and improper functionality of kidney cells. On the other hand tumor metastasis resulted in the decreased levels of anti-oxidative enzymes indicating increased oxidative stress in RCC patients. Conclusion: Our results show that the enhanced angiogenic property of serum and a downfall in anti-oxidative enzymes status could play a crucial role in renal cell carcinoma progression and metastasis in Punjabi population.

Keywords: Vascular endothelial growth factor, Sandwich ELISA, Lactate dehydrogenase and Glutathione reductase.

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