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Rani M. Umate*, Gouri R. Dixit, Kanchan P. Upadhye, Suparna S. Bakhale, Chetna S. Dakhate and Anup R. Thakre


The aim of this review is focused on the improvement of the solubility and bioavailability of poorly soluble drugs by using Crystal engineering approaches. Therapeutic effectiveness of a drug depends upon the bioavailability and ultimately upon the solubility of drug molecules especially in oral formulation. So many times it becomes challenging to formulate poorly water soluble drugs. Therefore it is necessary to improve solubility of drug by methods like co-solvency, salt formation, addition of solubilizing agent, micronization complexation, solid dispersion etc. A pharmaceutical co-crystal is a novel approach where single crystalline solid incorporates two neutral molecules, one being an active pharmaceutical ingredient (API) and the other a co-crystal former. Pharmaceutical co-crystals are nonionic supramolecular complexes and can be used to address physical property issues such as solubility, taste masking. This review cover the co-crystallization, techniques, properties and application in pharmaceutics.

Keywords: Bioavailability, BCS-II Cocrystal, Conformer, Solubility, Salt formation.

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