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Dewa Ayu Swastini*, I Gusti Agung Ayu Kartika, Anak Agung Wiradewi Lestari


The combination of Neutral Protamine Hagedorn (NPH) with Regular Human Insulin (RHI) and Glargine with Aspart insulin are two types of insulin combinations most frequently used to treat patients with type 2 diabetes mellitus who are hospitalized in the Sanglah Central General Hospital. This research has been conducted to compare the ability of these two insulin combinations to lower Blood Glucose Levels as well as to determine the percentage of the incidence of side effects. This research applied the observational analytic design (cohort). The characteristics of the patients and the incidence of side effects were analyzed descriptively while the data on blood glucose levels were analyzed evaluatively using paired T-test and independent T-test methods at 95% of confidence level. The results of the evaluative analysis showed that both combinations can reduce the Fasting Blood Glucose Levels, Postprandial Blood Glucose Levels and Random Blood Glucose Levels significantly, where the combination of Glargine insulin and Aspart insulin showed a greater reduction in blood sugar glucose level compared to the combination of NPH with RHI. The combination of NPH with RHI caused a greater incidence level of hypoglycemia but causes a lower incidence level of edema than the combination of Glargine with Aspart did. There’s no allergies finded both from two types of insulin combinations

Keywords: type 2 diabetes mellitus, blood glucose level, NPH, RHI, Glargine, Aspart, side effect.

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