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Y. Vishnu Vandana*, T. Manasa and G. Nookarathnam


In the present research, an attempt has been made to formulate controlled release matrix tablets of Bosentan. Bosentan is used to treat pulmonary arterial hypertension (PAH). It improves your ability to exercise and prevents your condition from getting worse. Different formulations were prepared by using different polymers like HPMC 50 CPS, HPMC E-5, karaya gum; Avicel PH102, PVP K30, Hydroxy Ethyl Cellulose and Talc etc. with different ratios were used in the development of formulations. HPMC 50 CPS, HPMC E-5 and karaya gum are used as rate controlling polymer, PVP K30 used as binder, microcrystalline cellulose as filler. The prepared tablets were evaluated for pre compression and post compression parameters with different ratios. All the evaluated parameters of the formulations showed compliance with pharmacopoeial standards. The selected formulations were subjected to stability studies as per ICH guidelines at different temperature and humidity conditions. It can be concluded that among all the formulations and the combinations of HPMC 50CPS, HPMC E-5, Avicel PH102 considered as the optimized formulations in the present research work. The optimized formulations show non-fickian diffusion mechanism of release and other all evaluation.

Keywords: Bosentan, HPMC 50 CPS, HPMC E-5, Karaya gum, Avicel PH102, PVP K30 and Magnesium stearate etc.

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