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Shaik Gouse Basha*, Moh Fassi Ahamed and Sameera Farnaaz


Herbal medicine sometimes referred to as Herbalism or Botonical medicine it includes use of herbs for treating pathological condition in the system. Herbal medicine have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. Diabetes mellitus (DM) is the name given to a multiple group of disorders with different etiologies. It is characterized by derangement in protein, carbohydrate, and fat metabolism caused by the complete or relative insufficiency of insulin secretion and/or insulin action. Diabetes is a major health problem worldwide as approximately 5% of the world’s population suffers from diabetes. Diabetes is a multifaceted disease involving impaired insulin secretion and insulin resistant. The loss of glycemic control, associated with these defects results in long-term complications which are both micro vascular (e.g.; retinopathy, nephropathy, neuropathy) and macro vascular (e.g.; stroke, myocardial infraction and peripheral vascular disease). The current treatment for both of diabetes delay, but do not prevent the micro vascular disease, leading in the long run to complications, including heart disease, stroke, blindness, kidney failure and limb amputation. Traditional plant medicines are used throughout the world for a range of Diabetic presentations. Therefore, investigation on such agents from traditional medicinal plants has become more important. India has a rich history of using various potent herbs and herbal components for treating Diabetes. Many Indian plants have been investigated for their beneficial use in different types of Diabetes. Foeniculum vulgare belonging to family Umbelliferae is mainly used as a food condiment the chief chemical constituent of fennel is volatile oils but it also contain ketone, fenchone, phellladrine. Pharmacologically it is used as anti-inflammatory, anti-oxidant, and hepatoprotective. Tagetes erecta of the family compositae is commonly found in parts of India, Asia, Africa and America. It is known as Marigold. The leaves are reported to be effective against piles, Kidney troubles, muscular Pain, ulcers, wound and earache. The herbs are used for the treatment of inflammatory conditions as a household remedy on experimental basis. The chief chemical constitutionsof Tagetes erecta is volatile oils, triterpinoids. The present study is mainly includes the extraction of Foeniculum vulgare and Tagetes erecta by using hydroalcohol with different concentration, and the extracts are test for its anti-diabetic activity individually and in combination for its synergistic anti diabetic activity. The test results are compared with the standard drug Glibinclamide, the Streptozotocin is used as a diabetic inducer in wister albino rats weighing 150-200 mg divided in six groups each group containing five rats in each group. The hydroalcoholic extract of Foeniculum vulgare and Tagetes erecta individually and in combination shown antidiabetic activity but it is not significant effect when the test results are compared with standard drug i.e Glibinclamide.

Keywords: Diabetes mellitus, Glibinclamide, Foeniculam vulgare, Tagetes erecta, Strepotozotocin.

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