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Abstract

DEVELOPMENT OF FAST RELEASE FORMULATION FOR DISSOLUTION RATE ENHANCEMENT

Versha Patel, *Arun Patel, Shailendra Patel, Neeraj Kaurav and Neelesh Devedi

ABSTRACT

The present work are to enhance the drug loading capacity in liquisolid system, increase the flow property due to decrement in required volume of nonvolatile solvent and enhance the solubility of drug in nonvolatile solvent by using mixed solvency concept. Naproxen was selected as model poorly water soluble drug for exploring the mixed solvency concept to enhance the solubility and hence to enhance the release rate of drug. The proposed formulation is aimed to enhance solubility of naproxen by employing mixed solvency concept and to develop the fast release capsule of naproxen by using liquisolid technique.

Keywords: Liquisolid system, Naproxen, mixed solvency concept.


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