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            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

CROSS-SECTIONAL STUDY IN NORTH EASTERN UTTAR PRADESH POPULATION FOR THE ASSESSMENT OF BETA CELL FUNCTIONS IN PATIENTS WITH RECENTLY DIAGNOSED TYPE 2 DIABETES MELLITUS TREATED WITH METFORMIN ALONE, METFORMIN WITH ADD ON SITAGLIPTIN & SITAGLIPTIN ALONE

Dr. Neerjesh*, Raj Kishore Singh, Vipender Singh Chopra, Akash Gajjar, O.N.Pandey and Praduman Mall

ABSTRACT

To assess the utility of Metformin & Sitagliptin alone over
combination of Metformin and Sitagliptin on function of β cells in
pancreas in patients with recently diagnosed type 2 Diabetes Mellitus.
Methods- This cross-sectional study includes analysis of total 75
patients who were divided in 3 groups. Metformin (2000mgs) group,
Sitagliptin (100 mgs) group, Combination group (Metformin 1000
mg+ Sitagliptin 50 mg). Various laboratory investigations were carried
out in all the subjects and findings were noted. Results- The highly
significant reduction (p<0.01) in Mean HbA1c in combined group of
Metformin and Sitagliptin as well as significant reduction in other
parameters for measuring blood Sugar in all the three groups (p<0.05)
were noted. Conclusions- These results suggest that the actions of DPP-4 inhibitors i.e.
Sitagliptin in combination with Metformin improve glycemic control as well as quality of life
(QOL).

Keywords: DPP-4 inhibitor, Metformin, Type 2 Diabetes mellitus, Beta cell function assessment.


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