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Abstract

APPLICATION OF COMPUTATIONAL STRATEGIES FOR OPTIMIZATION OF ASPARGINYL t-RNA SYNTHETASE DOCKING STUDY OF QUINOXALINES

Rahul Ingle*, Shailesh Wadher and Gajanan Sonwane

ABSTRACT

The potential use of asparginyl t-RNA synthetase inhibitors as antifilarial agents for the treatment of filariasis. In our present work we have synthesized series of diphenyl quinoxalines derivatives. Molecular docking studies of these compounds were undertaken to evaluate the binding affinities of the compounds with enzyme asparginyl t-RNA synthetase (PDB: 2kqr). The current result shows fine correlation in enzyme inhibitory activity with docked ligand.

Keywords: asparginyl t-RNA synthetase, quinoxaline, docking.


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