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Abstract

FORMULATION AND EVALUATION OF MICROSPONGES OF DICLOFENAC SODIUM

Dr. Gadhve Manoj V.*, Bankar Priyanka P., Jadhav S. L. and Dr. Gaikwad D. D.

ABSTRACT

Diclofenac sodium containing micro sponge as active constituent (API) in different formulations by changing the proportions of drug (diclofenac sodium), polymer (ethyl cellulose), emulsifier (Poly vinyl alcohol) were obtained successfully using quasi-emulsion solvent diffusion method.The micro sponges formulations were prepared by quasi emulsion solvent diffusion method employing ethyl cellulose as a polymer. The compatibility of the drug with formulation components was established by Fourier Transform Infra-Red (FTIR) spectroscopy. The surface morphology, particle size, production yield, and drug entrapment efficiency of micro sponges were examined. Shape and surface morphology of the micro sponges were examined using scanning electron microscopy. Particle size of prepared micro sponges was observed in the range of 28.7 ± 1.02 to 23.9 ± 1.19 μm. Scanning electron microscopy revealed the porous, spherical nature of the micro sponges. SEM photographs revealed the spherical nature of the micro sponges in all variations; however, at higher ratios, drug crystals were observed on the micro sponge surface. Increase in the drug/polymer ratio (1:1 to 1:10) increased their yield (10.85 ± 1.60 to 41.03 ± 1.26), average particle size of all formulations ranges from 28.7 μm to 45.9 μm which is in increasing order due to the increase in the concentration of polymer but after certain concentration it was observed that as the ratio of drug to polymer was increased, the particle size decreased, the drug content of different formulations was found in the range 19.07 ± 2.21 to 33.09 ±2.27, the cumulative release of the formulations are in the range of 89.83% to 13.25%.

Keywords: Ethyl Cellulose, Micro sponge Delivery System (MDS). Scanning Electron Microscopy (SEM), UV Spectroscopy.


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