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Abstract

DRUG UTILIZATION EVALUATION OF ANTI-EPILEPTICS IN A TERTIARY CARE TEACHING HOSPITAL

S. Parveen*, Dr. M. Madan Mohan Rao, MD*, Dr. R. Venkataramudu, MD* S. Arshiya Banu, T. Lavanya, J. Anbhuraj, K. Kranthi Kumar

ABSTRACT

Neurological diseases are gaining more importance in the developing
countries like India in recent times. Epilepsy is one of the most
important neurological disorders. It describes a condition in which a
person experience recurrent seizures due to a chronic, underlying
process. A Prospective Observational study was carried out at Rajiv
Gandhi Institute of Medical Sciences, Kadapa. A total of 65 patients
were selected in a 6 months period based upon the inclusion and
exclusion criteria. In the present study we made an attempt to conduct
Drug utilization evaluation (DUE) in epileptic patients to improve
treatment rationality in a tertiary care teaching hospital. Demographic
and prescription data was collected and assessed based upon the DUE.
From that we found that generalized seizures were the most prominent
seizure encountered and monotherapy was the most frequently used treatment in all types of
epileptic seizures. Our data suggests that unknown cause and stress is main offender of
symptomatic epilepsy. Furthermore, we observed that there was some inappropriate usage of
Anti-epileptic drugs which comprises drug-drug interaction and incorrect dosage regimen. we
found generalized seizures were the most prominent seizure encountered and monotherapy
was the most frequently used treatment in all types of epileptic seizures. Most commonly
prescribed drug was Phenytoin. We found ADRs, medication errors and drug interactions in this study and we did interventions too. Through this study we brought awareness about DUE in both health care professionals and in patients.

Keywords: Epilepsy, Anti-epileptic drugs, Drug utilization evaluation, Monotherapy.


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