FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF MELOXICAM
*M. Chaitanya, Ch. Srinivas Reddy and G. Babu
ABSTRACT
Meloxicam is a newer preferantionalCOX-1 inhibitor, has been used to
relieve the symptoms of arthritis, primary dysmenorrhea, fever and as
an analgesic, especially where there is an inflammatory component.
The present work aimed at preparing oral fast quick onset of action,
which is very convenient for administration, without the problem of
swallowing and using water. Oral fast dissolving films of Meloxicam
were prepared using HPMC ( E5, E15) polymers as film forming
agents and PEG 400 as plasticizerby solvent casting method. FTIR
showed that there is no interaction between drug and excipients.
Dissolution of prepared fast dissolving oral films of Meloxicam was performed using USP
type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being
maintained at 37 0.5ÂșC. The films prepared were evaluated for various parameters like
thickness, percent elongation, drug content uniformity, weight variation, disintegration time,
folding endurance and in vitro drug release and were showed satisfactory results. In
conclusion, development of fast dissolving oral films using HPMC E5 300 polymer gives
rapid drug delivery and rapid onset of action.
Keywords: Meloxicam, Oral fast dissolving films.
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