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Abstract

SYNTHESIS AND BIOLOGICAL SCREENING OF (E)-3-{[(3′- DIFLUOROMETHOXY)-5′-(3″-METHYL)-4″-(2‴, 2‴, 2‴- TRIFLUOROETHOXY)PYRIDIN-2″-YL]METHOXYPHENYL}-1- ARYL-PROP-2-ENE-1-ONES

Sandip P. Kakadiya, Heta D. Purohit, Dipak M. Purohit*

ABSTRACT

Chalcones are intermediate compounds to synthesis of many heterocyclic compounds. They are especially interesting for their biological and industrial application. (E)-3-{[(3′-Difluoromethoxy)-5′- (3″-methyl)-4″-(2‴,2‴,2‴-trifluoroethoxy) pyridine-2″- yl]methoxyphenyl}-1-aryl-prop-2-ene-1-ones (4a-4k) have been synthesized by the condensation of 3-Difluoromethoxy-4-{[(3′-methyl)- 4′-(2″,2″,2″-trifluoro ethoxy)pyridin-2′-yl]methoxyphenyl}-1- carboxaldehyde with aromatic ketones in presence of aqueous NaOH. All synthesized compounds characterized with IR, 1H NMR, Mass spectra, TLC and physical constants. All the synthesized compounds evaluated for their antimicrobial activity against Gram +ve bacteria (B.mega, B.Subtillis) Gram -ve bacteria (E.coli, P.fluorescens) and fungi (A.awamori).

Keywords: Chalcones, Anti-microbial activity; (Heterocyclic Compounds).


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