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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

POLYETHYLENE GLYCOL (PEG-400): AN EFFICIENT GREEN REACTION MEDIUM FOR THE ALKYLATION OF 3, 4-DIHYDROXY THIOPHENE-2, 5-DICARBOXYLIC ESTERS OR THEIR ALKALI METAL OR ALKALINE EARTH METAL SALTS.

The present invention relates to an improved process for the alkylation
of 3, 4- dihydroxythiophene-2, 5-dicarboxylic esters or their alkali
metal or alkaline earth metal salts with alkylating agent and base in the
presence of a solvent and catalyst PEG-400 was used as a Phase
transfer Catalyst and could effectively catalyze the Reaction.

ABSTRACT

The present invention relates to an improved process for the alkylation of 3, 4- dihydroxythiophene-2, 5-dicarboxylic esters or their alkali metal or alkaline earth metal salts with alkylating agent and base in the presence of a solvent and catalyst PEG-400 was used as a Phase transfer Catalyst and could effectively catalyze the Reaction.

Keywords: 3, 4-alkylenedioxythiophenedicarboxylic acid or its salts, 3, 4- dihydroxy thiophene-2, 5-dicarboxylic esters or their alkali metal or alkaline earth metal salts, PEG-400.


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